Diversity oriented synthesis of chromene-xanthene hybrids as anti-breast cancer agents.
| Author | |
|---|---|
| Abstract |
:
A diverse library of chromene-xanthene hybrids were synthesized through intramolecular Friedel-Crafts reaction of the arenoxy carbinols. Examples include first incorporation of amino acid tyrosine into xanthene skeletons with polar functionalities. A careful structural evaluation revealed that tyrosine crafted chromene-xanthene hybrids exhibited good activities against breast cancer cell lines MCF-7, MDA-MB-231. The lead compound 16 displays significant cell cycle arrest at G1 phase and induces apoptosis in MDA-MB-231 cells. |
| Year of Publication |
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2018
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| Journal |
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Bioorganic & medicinal chemistry letters
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| Date Published |
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2018
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| ISSN Number |
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0960-894X
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| URL |
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http://linkinghub.elsevier.com/retrieve/pii/S0960-894X(17)31239-8
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| DOI |
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10.1016/j.bmcl.2017.12.065
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| Short Title |
:
Bioorg Med Chem Lett
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| Download citation |
