Assessing the effect of a partly unobserved, exogenous, binary time-dependent covariate on survival probabilities using generalised pseudo-values.
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Abstract |
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Investigating the impact of a time-dependent intervention on the probability of long-term survival is statistically challenging. A typical example is stem-cell transplantation performed after successful donor identification from registered donors. Here, a suggested simple analysis based on the exogenous donor availability status according to registered donors would allow the estimation and comparison of survival probabilities. As donor search is usually ceased after a patient's event, donor availability status is incompletely observed, so that this simple comparison is not possible and the waiting time to donor identification needs to be addressed in the analysis to avoid bias. It is methodologically unclear, how to directly address cumulative long-term treatment effects without relying on proportional hazards while avoiding waiting time bias. |
Year of Publication |
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2018
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Journal |
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BMC medical research methodology
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Volume |
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18
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Issue |
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1
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Number of Pages |
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14
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Date Published |
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2018
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URL |
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https://bmcmedresmethodol.biomedcentral.com/articles/10.1186/s12874-017-0430-5
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DOI |
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10.1186/s12874-017-0430-5
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Short Title |
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BMC Med Res Methodol
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