Genomic Characterization of Biliary Tract Cancers Identifies Driver Genes and Predisposing Mutations.

Author
:
CP Wardell
M Fujita
T Yamada
M Simbolo
M Fassan
R Karlic
P Polak
J Kim
Y Hatanaka
K Maejima
RT Lawlor
Y Nakanishi
T Mitsuhashi
A Fujimoto
M Furuta
A Ruzzenente
S Conci
A Oosawa
A Sasaki-Oku
K Nakano
H Tanaka
Y Yamamoto
K Michiaki
Y Kawakami
H Aikata
M Ueno
S Hayami
K Gotoh
SI Ariizumi
M Yamamoto
H Yamaue
K Chayama
S Miyano
G Getz
A Scarpa
S Hirano
T Nakamura
H Nakagawa
Abstract
:

Biliary tract cancers (BTCs) are clinically and pathologically heterogeneous with poor response to treatments. Genomic profiling can offer a clearer understanding of their carcinogenesis, classification and treatment strategy. We performed large scale genome sequencing analyses on BTCs to investigate their somatic and germline driver events and characterize their genomic landscape.
Year of Publication
:
2018
Journal
:
Journal of hepatology
Date Published
:
2018
ISSN Number
:
0168-8278
URL
:
http://linkinghub.elsevier.com/retrieve/pii/S0168-8278(18)30021-7
DOI
:
10.1016/j.jhep.2018.01.009
Short Title
:
J Hepatol
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