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Model Interpretation and Clinical Implications.

Author
Abstract
:

Useful characterizing parameters have been derived from historical positron emission tomography (PET) standardized uptake values (SUV) and influx constants K. Meta-analysis was performed on 30 multipatient PET oncological studies providing same patient SUVs and K's. Averaged results for fluorine-18 fluorodeoxyglucose (FDG) and L-methionine respectively were: SUV vs. K correlation coefficients = 0.89 and 0.80; SUV/K ratios = 192 and 63 minutes as average tracer clearance times T in these populations. For cancers, coefficients of variation (CV) for K's were 0.61 and 0.46, notably larger than the CVs (0.50 and 0.40) for SUVs. A Monte Carlo simulation model, matching these results, represents 1/T as (an effective tracer clearance rate) x (its initial distribution volume). We conclude that T is a characteristic tracer clearance time that is independent of cancer type. A measurement model is introduced that might help improve protocols. The higher CVs of K's vs. SUVs is worth noting clinically when seeking an effective diagnostic marker. Also, SUV conversions to K can provide some quality assurance in K measurements.

Year of Publication
:
1999
Journal
:
Clinical positron imaging : official journal of the Institute for Clinical P.E.T
Volume
:
2
Issue
:
2
Number of Pages
:
99-104
ISSN Number
:
1095-0397
URL
:
https://linkinghub.elsevier.com/retrieve/pii/S1095039799000114
DOI
:
10.1016/s1095-0397(99)00011-4
Short Title
:
Clin Positron Imaging
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