The purpose of this study was to examine the utility of using the NEO-FFI personality assessment as part of multi-dimensional psychological assessment in orofacial pain patients during the initial diagnostic visit. All patients completed an orofacial pain questionnaire and a battery of psychological questionnaires that cover a wide range of symptoms and behaviors important to developing a comprehensive treatment plan. For purposes of the present study, the NEO-FFI was included. Personality characteristics were within normal ranges compared to NEO-FFI norms. Regression analyses demonstrated higher self-reported pain severity was associated with lower openness. Higher psychological distress was associated with higher neuroticism, lower extraversion, and lower openness. In patients reporting a traumatic life experience, neuroticism and extraversion mediated the relationship between trauma-symptoms and psychological distress. The addition of a global personality measure in standard assessment batteries may help the clinician develop coping strategies and techniques based on individual characteristics of the pain patient. Greater understanding of the individual's personality characteristics will likely influence the nature of the pain management program and predict treatment outcomes.