The commercialization of university-based research occurs to varying degrees between academic institutions. Previous studies have found that multiple barriers can impede the effectiveness and efficiency by which academic research is commercialized. This case study was designed to analyze the status of the commercialization activity at the University of Kentucky via a survey and interview with a successful academic entrepreneur in order to determine the impediments the individual perceived during the commercialization process. The study also garnered insight from the individual as to how the commercialization process could be improved. Issues with infrastructure were highlighted as the most significant barrier faced by the individual. The research subject also suggested that commercialization activity may generally increase if a number of factors were mitigated. Such insight can be communicated to the administrative leadership of the commercialization process at the University of Kentucky. Long term, improving university-based research commercialization will allow academic researchers to be more active and successful entrepreneurs such that intellectual property will progress more freely to the marketplace for the benefit of inventors, universities, and society.