Aesculetin (6,7-dihydroxycoumarin) exhibits potent and selective antitumor activity in human acute myeloid leukemia cells (THP-1) via induction of mitochondrial mediated apoptosis and cancer cell migration inhibition.
| Author | |
|---|---|
| Abstract |
:
The main target of the present research was to examine the antitumor properties of aesculetin in human acute myeloid leukemia cancer cells (THP-1) and peripheral blood mono-nucleated cells (PBMCs) (used as normal cell line model) along with the determination of its effects on induction of apoptosis, inhibition of cancer cell migration and changes in Bcl-2/Bax protein expressions. |
| Year of Publication |
:
1969
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| Journal |
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Journal of B.U.ON. : official journal of the Balkan Union of Oncology
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| Volume |
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22
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| Issue |
:
6
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| Number of Pages |
:
1563-1569
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| Date Published |
:
1969
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| ISSN Number |
:
1107-0625
|
| Short Title |
:
J BUON
|
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